Autophagy and ageing: Insights from invertebrate model organisms

Reproductive aging: insights from model organisms.

Aging was once thought to be the result of a general deterioration of tissues as opposed to their being under regulatory control. However, investigations in a number of model organisms have illustrated that aspects of aging are controlled by genetic mechanisms and are potentially manipulable, suggesting the possibility of treatment for age-related disorders. Reproductive decline is one aspect o...

Invertebrate insights into autism.

characterized by deficits in social communication and interaction, impaired language development, and stereotyped repetitive behaviors. The broader category of autism spectrum disorders (ASDs) includes individuals with subsets of these symptoms (Geschwind and Levitt, 2007). The prevalence of autism in the USA has increased since the inception of the diagnosis in the 1980s – to about 1 in every ...

Autophagy and immunity – insights from human herpesviruses

The herpesviruses are a family of double-stranded DNA viruses that infect a wide variety of organisms. Having co-evolved with their hosts over millennia, herpesviruses have developed a large repertoire of mechanisms to manipulate normal cellular processes for their own benefit. Consequently, studies on these viruses have made important contributions to our understanding of fundamental biologica...

Drug repurposing for ageing research using model organisms

1 European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), The Genome Campus, Hinxton, Cambridge CB10 1SD, UK; 2 Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK 3 Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Str. 9b, 50931 Cologne, Germany $ current address: M...

Autophagy--alias self-eating--appetite and ageing.